NACET: Nootropic Benefits, Dosage, & Side Effects

NACET (N-Acetylcysteine ethyl ester) represents a powerful antioxidant supplement that enhances glutathione production while offering superior bioavailability compared to standard NAC supplements. NACET crosses cell membranes efficiently due to its lipophilic properties, making it 20 times more bioavailable than traditional glutathione and NAC supplements.

NACET protects brain cells from oxidative damage while supporting cognitive function through its neuroprotective effects. NACET boosts immune health by fortifying the body’s defense systems against various health challenges.

As a chemical derivative of L-cysteine, NACET combines NAC Ethyl Ester with glycine, selenium, and molybdenum to create a formula designed specifically for enhanced absorption and utilization within the body.

What is NACET?

NACET (N-Acetylcysteine ethyl ester) is a powerful antioxidant supplement that enhances glutathione production, which protects against oxidative damage while offering superior bioavailability compared to standard NAC supplements.

This chemical derivative of L-cysteine (an amino acid) is more than just another supplement; it’s a potent antioxidant formula designed to significantly boost brain and immune health.⁽¹⁾ It includes NAC (N-acetyl cysteine) Ethyle Ester, Glycine, Selenium, and Molybdenum.

What sets NACET apart is its remarkable bioavailability, which is 20x more bioavailable than your standard Glutathione and NAC supplements. This means that when you take NACET, your body utilizes it more effectively.

This enhanced bioavailability translates into more potent antioxidant effects, particularly in boosting levels of the antioxidant glutathione (GSH), known as the body’s most powerful antioxidant.

NACET’s ability to fend off oxidative damage to cells makes it a double-edged blade in health maintenance. It not only helps protect the brain from free radical damage but also supports cognitive function, making it a perfect ally for long-term brain health.

Moreover, its role in immune health cannot be overstated; it helps fortify the immune system, offering protection against various health challenges.

So, whether you’re looking to boost your cognitive abilities, protect your body from oxidative damage, or support your immune system, NACET emerges as a top choice.

Its combination of high-quality ingredients, backed by research and a commitment to health, makes it not just a supplement but a powerful tool in your wellness regimen.

Pros:

• Promotes improved cognitive function and brain health
• Superior bioavailability compared to standard NAC and glutathione supplements
• Anti-aging effects from the boost of glutathione production
• Neuroprotective effects that protect the brain from oxidative stress

Cons:

• Not approved by the FDA (Food and Drug Administration)
• Lacking scientific research to back its specific benefits and long-term effects

Mechanism of Action

NACET, the ethyl ester form of N-Acetyl L-Cysteine (NAC), functions in the body through a distinct mechanism of action, primarily centered around its role as a precursor to glutathione and its enhanced bioavailability compared to standard NAC.

• Conversion to N-Acetylcysteine (NAC): Once ingested, NACET works by crossing cell membranes efficiently due to its lipophilic (fat-soluble) ethyl ester group, which allows for better absorption through lipid membranes before converting to NAC and ultimately boosting glutathione production throughout the body and brain.
• Boosting Glutathione Levels: NAC is a precursor to glutathione, one of the body’s most crucial antioxidants. Glutathione plays a vital role in neutralizing free radicals, reducing oxidative stress, and supporting the detoxification process in the liver. By increasing glutathione levels, NACET helps protect cells from oxidative damage, which is important for maintaining cellular health and preventing aging-related damage.
• Direct Antioxidant Activity: Apart from being a precursor to glutathione, NAC itself has antioxidant properties. It directly scavenges free radicals, thereby contributing to its protective effects against oxidative stress.
• Modulation of Neurotransmitter Activity and Inflammation: NACET, through its conversion to NAC, may influence the levels of glutamate in the brain. Glutamate is an important neurotransmitter involved in learning and memory. It also has anti-inflammatory effects. NAC has been shown to modulate the production of certain cytokines, which are signaling molecules that mediate and regulate immunity, inflammation, and hematopoiesis.
• Mucolytic Action: NAC, the active form derived from NACET, also acts as a mucolytic agent by breaking disulfide bonds in mucus, making it less viscous and easier to expel. This property is particularly useful in conditions like chronic obstructive pulmonary disease (COPD) and bronchitis.

Nootropic Benefits of NACET

NACET is gaining attention in the nootropic community for its ability to improve cognitive functions and brain health. Its enhanced absorption over traditional NAC allows for better utilization within the brain, leading to various positive effects on mental performance and brain protection.

But, how exactly does NACET improve your cognitive health?

Here’s a list of the key nootropic benefits of NACET.

1. Enhances Glutathione Production

NACET boosts the production of glutathione, a key antioxidant in the brain. This helps in reducing oxidative stress and neuronal damage, which is crucial for maintaining cognitive health.⁽²⁾

2. Neuroprotective Properties

The antioxidant effects of NACET provide neuroprotection, which is valuable in preventing age-related cognitive decline and protecting against environmental neurotoxins.

By increasing antioxidant levels, NACET protects brain cells from oxidative stress, which otherwise impair cognitive functions and lead to neurodegenerative diseases.⁽³⁾

3. Modulates Neurotransmitter Levels

NACET influences neurotransmitters like glutamate, which plays a vital role in learning and memory. Balanced glutamate levels are essential for proper brain function.⁽⁴⁾

4. Improves Mental Health

NACET has been shown to have beneficial effects on mental health, potentially aiding in the management of conditions like depression and anxiety due to its impact on neurotransmitter regulation.⁽⁵⁾

5. Supports Cognitive Function

By protecting neurons and balancing neurotransmitters, NACET supports overall cognitive function, including memory, attention, and mental clarity.

6. Enhances Brain Blood Flow

Improved brain blood flow is essential for cognitive performance, and NACET’s role in vascular health contributes to better cerebral circulation.

7. Reduces Inflammatory Responses in the Brain

NACET modulates the inflammatory pathways in the brain, which is beneficial in reducing the risk of neuroinflammation-related cognitive impairment.⁽⁶⁾

Uses of NACET

NACET is utilized for a variety of health-related purposes due to its enhanced bioavailability and potent antioxidant properties.

Here are some of the primary uses of NACET:

1. Boosting Antioxidant Levels: NACET is highly effective in increasing the body’s production of glutathione, a powerful antioxidant. This makes it useful in combating oxidative stress and protecting cells from damage.
2. Supporting Brain Health: Due to its potential neuroprotective properties, NACET is used to support brain health, enhance cognitive functions, and may help in the management of neurodegenerative diseases.
3. Enhancing Immune Function: By boosting glutathione levels, NACET strengthens the immune system, helping the body fight off infections and diseases more effectively.
4. Detoxification: NACET is used in detoxifying the liver, especially in cases of acetaminophen (Tylenol) overdose, where it helps to prevent liver damage by restoring glutathione levels.
5. Respiratory Health: As a mucolytic agent, NACET helps in breaking down mucus, making it beneficial for individuals with chronic respiratory conditions like COPD or bronchitis.
6. Psychiatric and Neurological Disorders: NACET is being explored for its potential benefits in treating psychiatric and neurological disorders, such as depression, anxiety, and bipolar disorder, due to its impact on neurotransmitters and neuroprotection.⁽⁷⁾
7. Reducing Inflammatory Conditions: Its anti-inflammatory properties make NACET useful in managing chronic inflammatory conditions.
8. Athletic Performance: Athletes may use NACET to reduce oxidative stress and improve recovery times after intense physical activity.
9. Skin Health: NACET’s antioxidant properties can also be beneficial for skin health, helping to protect against damage from free radicals and possibly reducing signs of aging.
10. Addiction Treatment: Some studies suggest that NACET could be beneficial in treating certain addictions by modulating neurotransmitter systems involved in addictive behavior.⁽⁸⁾

NACET as a Dietary Supplement

In the expanding market of dietary supplements, NACET stands out as a premium option for those seeking enhanced antioxidant support. Unlike standard glutathione supplements that suffer from poor bioavailability, or regular NAC which has limited absorption, NACET’s unique ethyl ester formulation allows it to cross cell membranes more efficiently, making it a superior choice in the glutathione-boosting supplement category.

When comparing NACET to other antioxidant supplements like standard NAC, liposomal glutathione, or alpha-lipoic acid, NACET’s enhanced bioavailability offers a significant advantage. While these alternatives may require higher doses or more frequent administration to achieve similar effects, NACET’s efficient absorption means you can potentially take lower doses less frequently.

For optimal absorption, NACET is best taken with food, particularly meals containing some healthy fats that can enhance the absorption of this lipophilic compound. However, it can also be taken on an empty stomach if necessary, with minimal risk of gastrointestinal discomfort compared to standard NAC.

NACET works well in combination with other supplements, particularly those that support glutathione synthesis or antioxidant function. Complementary supplements include selenium, which is a cofactor for glutathione peroxidase enzymes, vitamin C which helps regenerate oxidized glutathione, and B vitamins that support methylation pathways involved in glutathione production.

When selecting a NACET supplement, quality matters significantly. Look for products that provide third-party testing results, certificates of analysis, and clear information about purity and potency. Reputable manufacturers will typically provide this information readily, ensuring you’re getting a product free from harmful contaminants and with verified potency.

As part of a comprehensive supplement regimen, NACET can serve as a cornerstone antioxidant support, particularly for those concerned with cognitive health, immune function, or detoxification capacity. Its effects complement other targeted supplements, making it a valuable addition to personalized supplement protocols rather than a standalone solution.

Where to Buy NACET

The search to find a reliable nootropics retailer online can be grueling, and sometimes costly.

Luckily, we have done an in-depth analysis to source the best online vendor for NACET.

Science.Bio provides the best quality NACET powder, with third-party testing, shipping to your door, and positive customer reviews, we are sold on this world-renowned company!

NACET Powder: Usage Guide

NACET powder is the most common form of this supplement available from retailers like Science.Bio. This fine, white crystalline powder has a slightly sulfurous odor and a mildly bitter taste due to its sulfur-containing compounds.

When working with NACET powder, precision is crucial due to its potency. A micro-scale accurate to at least 0.01 grams is recommended for proper measurement, as even small variations in dosage can affect your experience with this supplement.

To consume NACET powder effectively, mix your measured dose with water, juice, or another beverage of your choice. Due to its enhanced solubility—over 100 times more soluble than standard NAC—NACET powder dissolves relatively well in liquids. However, some users prefer to use a small amount of warm water first to dissolve the powder completely before adding it to their preferred beverage.

For those sensitive to the taste, mixing NACET powder with fruit juice or flavored beverages can help mask its slightly bitter profile. Alternatively, some users opt to encapsulate the powder using empty gelatin or vegetable capsules available from supplement suppliers.

Proper storage of NACET powder is essential to maintain its potency. Keep it in an airtight container away from direct sunlight, heat, and moisture. Refrigeration is not necessary but can help preserve freshness, especially in warm or humid climates. When properly stored, NACET powder typically maintains its potency for up to two years from the manufacturing date.

NACET Dosage

For general health purposes, NAC (N-Acetyl L-Cysteine) supplements are typically taken in doses ranging from 600 to 1800 mg per day, usually divided into multiple doses.

Since NACET is more potent due to better absorption, the required dosage might be lower.

Here are some general NACET dosage guidelines:

• For Antioxidant Support and General Health: A lower dose, possibly in the range of 300-600 mg per day, could be sufficient, considering NACET’s enhanced bioavailability.
• For Specific Health Conditions: Higher doses might be required, but it’s crucial to consult a healthcare provider for guidance. Conditions such as chronic respiratory diseases or acute liver damage due to acetaminophen overdose (where NAC is traditionally used) might require specific dosing regimens.
• For Cognitive or Neuroprotective Effects: Doses in the moderate range, similar to or slightly lower than standard NAC doses, may be effective, but again, specific dosing should be determined by a healthcare professional.
• Frequency of Dosing: NACET might be taken once or twice daily, depending on the total daily dosage and the purpose of supplementation.

NACET begins working immediately after absorption, with glutathione-boosting effects starting within hours, though noticeable cognitive benefits typically require consistent daily supplementation for 2-4 weeks as the cumulative antioxidant effects build up in brain tissue and neurological systems.

NACET Side Effects and Safety

NACET is generally safe for most healthy adults when taken at recommended dosages, though as a derivative of N-Acetyl L-Cysteine (NAC), it shares similar safety considerations including potential interactions with certain medications and rare allergic reactions in sensitive individuals. However, due to its enhanced bioavailability, the intensity and occurrence of these side effects may differ. It’s important to note that while NACET is considered safe for most people when taken as recommended, there are some potential side effects and safety considerations to be aware of.

Common side effects include:

• Gastrointestinal discomfort
• Headaches
• Dizziness
• Dry mouth

These are usually short-lived and disappear once your body adjusts to the NACET supplement.

Less common side effects include:

1. Bad Breath and Body Odor: Due to its sulfur content, NACET can cause an unpleasant odor.
2. Allergic Reactions: Rarely, allergic reactions like rash, itching, or difficulty breathing can occur, which would require immediate medical attention.

Safety Considerations:

1. Asthma and Bronchospasm: People with asthma need to be cautious as NAC can cause bronchospasm. It’s advised to start with a lower dose and monitor symptoms.
2. Interactions with Medications: NACET can interact with certain medications, including nitroglycerin and other nitrate medications used for heart conditions, which can cause severe headaches and other side effects.
3. Bleeding Disorders: NACET may slow blood clotting. People with bleeding disorders or those on blood-thinning medications should be cautious.
4. Surgery: Due to its potential effects on blood clotting, it’s recommended to stop using NACET at least two weeks before a scheduled surgery.

Summary

In conclusion, NACET, the ethyl ester form of N-Acetyl L-Cysteine, emerges as a compelling addition to the world of health supplements.

Its enhanced bioavailability and potent antioxidant properties make it a standout choice for those seeking to bolster their overall health, particularly in areas of brain function, immune support, and detoxification.

While its benefits are manifold, ranging from neuroprotection to respiratory health support, it is crucial to approach NACET with a balanced perspective. Acknowledge both its potential and its limitations.

Therefore, users must consult healthcare professionals before incorporating it into their regimen, especially those with pre-existing conditions or those on medication.

FAQs

1. Giustarini, Daniela et al. “N-Acetylcysteine ethyl ester (NACET): a novel lipophilic cell-permeable cysteine derivative with an unusual pharmacokinetic feature and remarkable antioxidant potential.” Biochemical pharmacology vol. 84,11 (2012): 1522-33. doi:10.1016/j.bcp.2012.09.010↩
2. Giustarini, Daniela et al. “N-acetylcysteine ethyl ester as GSH enhancer in human primary endothelial cells: A comparative study with other drugs.” Free radical biology & medicine vol. 126 (2018): 202-209. doi:10.1016/j.freeradbiomed.2018.08.013↩
3. Tosi, Gian Marco et al. “Superior Properties of N-Acetylcysteine Ethyl Ester over N-Acetyl Cysteine to Prevent Retinal Pigment Epithelial Cells Oxidative Damage.” International journal of molecular sciences vol. 22,2 600. 9 Jan. 2021, doi:10.3390/ijms22020600↩
4. Bavarsad Shahripour, Reza et al. “N-acetylcysteine (NAC) in neurological disorders: mechanisms of action and therapeutic opportunities.” Brain and behavior vol. 4,2 (2014): 108-22. doi:10.1002/brb3.208↩
5. Kukoc-Modun, Lea et al. “Determination of N-Acetyl-l-cysteine Ethyl Ester (NACET) by Flow Injection Analysis and Spectrophotometric Detection Using Different Thiol-Sensitive Ligands.” Molecules (Basel, Switzerland) vol. 26,22 6826. 11 Nov. 2021, doi:10.3390/molecules26226826↩
6. Bradlow, Richard C J et al. “The Potential of N-Acetyl-L-Cysteine (NAC) in the Treatment of Psychiatric Disorders.” CNS drugs vol. 36,5 (2022): 451-482. doi:10.1007/s40263-022-00907-3↩
7. Smaga, Irena et al. “N-acetylcysteine as a new prominent approach for treating psychiatric disorders.” British journal of pharmacology vol. 178,13 (2021): 2569-2594. doi:10.1111/bph.15456↩
8. Ooi, Soo Liang et al. “N-Acetylcysteine for the Treatment of Psychiatric Disorders: A Review of Current Evidence.” BioMed research international vol. 2018 2469486. 22 Oct. 2018, doi:10.1155/2018/2469486↩